Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. J Eur Acad Dermatol Venereol. COVID19 MapJohns Hopkins Coronavirus Resource Center. Erythematous-squamous, annular plaque on the presternal region. Cutaneous adverse reactions of COVID-19 vaccines: A systematic review. Rashes show as hives, bumps or . Ciccarese G, Parodi A, Drago F. SARS-CoV-2 as possible inducer of viral reactivations. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. The first sign of pityriasis rosea is often one large patch on the skin, which is followed smaller patches or bumps. 10.7499/J.ISSN.1008-8830.2101133 Epub 2021 Jun 10. Dermatol Reports. Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. It often presents with diffuse and confluent severely pruritic dusky-red erythematous lesions in the absence of herald patch (11). Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID19). Reply to "the significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations" by Ciccarese G. et al. 2021;35(8):e489e491. Manifestation of pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccine: A systematic review. Dermatol Reports. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. NCI CPTC Antibody Characterization Program, Ritchie H., Mathieu E., Rodes-Guirao L., et al. However, some hypotheses may be advanced: PR/PRLE following anti-Sars-CoV-2 vaccination may be just a coincidence; anti-Sars-CoV-2 vaccines cause a reactivation of HHV-6 and/or HHV-7; vaccines can induce a delayed hypersensitivity response clinically similar to drug-induced PRLE. Moreover, central dusky-red erythematous was observed on some plaques (Figure 2A). FOIA All patients are currently in good general health. Pityriasis rosea developing after COVID-19 vaccination. Here, we report the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. It can take 1 to 3 months to go away. Federal government websites often end in .gov or .mil. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Curr Dermatol Rep. 2022;11(4):289-312. doi: 10.1007/s13671-022-00370-9. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Blumenthal KG, Fox LP, Freeman EE. Epub 2022 Jan 5. official website and that any information you provide is encrypted Epub 2021 May 29. PRISMA flowchart. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. 8600 Rockville Pike Pityriasis versicolor is caused by a yeast infection and can be treated with antifungal medicines , including antifungal creams and antifungal shampoos. This site needs JavaScript to work properly. We observed Leerunyakul K, Pakornphadungsit K, Suchonwanit P. Front Med (Lausanne). Factors affecting the severity of central centrifugal cicatricial alopecia. The clinics of HHV-6 infection in COVID-19 pandemic: pityriasis rosea and Kawasaki disease. Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. We speculate that PR could be a delayed skin manifestation of COVID-19 infection, triggered either by SARS-CoV-2 immediately or indirectly by the reactivation of other viruses such as HHV-6 or HHV-7. SPSS statistical software version 25 was used for appropriate inferential statistics. government site. Histopathologic examination revealed epidermal focal spongiosis, interface dermatitis with necrotic keratinocytes, perivascular lymphocytic infiltration, and few eosinophilic infiltrations in the superficial dermis (Figures 3B,C). Careers. The .gov means its official. sharing sensitive information, make sure youre on a federal We include a review on all cases of PR/PRLE after anti- SARS-CoV-2 vaccination reported in the literature and discuss some pathogenetic hypotheses. The vaccination campaign has been the most important strategy to combat the COVID-19 pandemic. Pityriasis versicolor is another common skin condition that can be confused with pityriasis rosea, as the rash may look similar. Abdullah L, Hasbani D, Kurban M, Abbas O. Pityriasis rosea after mRNA COVID-19 vaccination, Two cases of pityriasis rosea after the injection of coronavirus disease 2019 vaccine, Erythema nodosum, zoster duplex and pityriasis rosea as possible cutaneous adverse effects of Oxford-AstraZeneca COVID-19 vaccine: report of three cases from India, Atypical pityriasis rosea associated with mRNA COVID- 19 vaccine, Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male, Pityriasis rosea-like cutaneous eruption as a possible dermatological manifestation after Oxford-AstraZeneca vaccine: case report and brief literature review. Cutis. 2023 Mar 29;13(7):1286. doi: 10.3390/diagnostics13071286. 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. J Med Virol. World J Clin Cases. See this image and copyright information in PMC. 8600 Rockville Pike Drago F, Ciccarese G, Javor S, Parodi A. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. The association between pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccines was established, but given the scarcity of studies, there is a need to conduct different clinical trials to confirm this association further and study the etiology and mechanism of the disease. An official website of the United States government. Human herpesvirus-6,7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. MeSH Physical examination revealed that lesions were distributed along cleavage lines, similar to PR, without herald patch or prominent scales (Figure 1C). The exanthem was self-limited in both patients over a period of a month. We report 10 . Department of Dermatology, Graduate School of Medicine, Kyusyu University, Japan. It is believed to represent a delayed reaction to viral infections and is usually associated with endogenous systemic reactivation of human herpesvirus (HHV) 6 and / or 7 (1). 1. Although histopathologic characteristics of PR are also observed in PR-like lesions, the presence of dyskeratotic keratinocytes, interface dermatitis, and eosinophilic infiltration in the dermis may be more prominent in PR-like eruptions (11). Pityriasis rosea is a rash that often begins as an oval spot on the face, chest, abdomen or back. Epub 2022 Feb 9. Additionally, differences in incidence of this reaction after Pfizer and Moderna vaccination may suggest a differing host immune response incited by these vaccines which warrants further investigation. J Eur Acad Dermatol Venereol 2020; 34: e436-e437. Four patients were subjected to the second vaccination, but no skin lesions appeared. Databases were searched, covering a timeline from December 1, 2019 to February 28, 2022. Nevertheless, she did not present with fever or respiratory tract symptoms. A 46-year-old man presented to our Department with a two-week history of skin rash associated with mild pruritus. 2021 Sep;34(5):e15040. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. In our study we observed 2 cases of EM after covid19 vaccine , one occurred after the BBIBP-CorV vaccine while the other was observed after ChAdOx1 nCoV- 19 vaccine. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine. Careers. and transmitted securely. -, Wollina U, Chiriac A, Kocic H, Koch A, Brzezinski P. Cutaneous and hypersensitivity reactions associated with COVID19 vaccinationa narrative review. We study 2,437 people who have Abdominal fullness prematurely after meals or Pityriasis rosea. (2015) 2015:253154. doi: 10.1155/2015/253154, 14. Department of Pathophysiology and Transplantation, Universit degli Studi, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy. Bookshelf FOIA PMC 2022 Jul 21;14(7):e27108. In 3 patients a biopsy for histopathological examinations was carried out. He described the appearance of an erythematous centrally scaled lesion at the right part of his abdomen, followed by the spreading of red oval mildly scaling lesions on the trunk, neck, and proximal parts of the upper extremities, which showed in the physical examination (Figure 1, a and b). sharing sensitive information, make sure youre on a federal Human herpesvirus-6, -7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. They are described as small, itchy blisters found on the trunk of the body and filling with blood, present in middle-aged patients. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. MeSH Patients characteristics are reported in Table 1. Epub 2022 Mar 8. [Epub ahead of print]. The average age of incidence was calculated to be 44.92 years, and 63 (62.37%) people presented after administration of the first dose. It is also called Christmas tree rash. Before eCollection 2022. 8:752443. doi: 10.3389/fmed.2021.752443. eCollection 2023 Mar 7. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. Careers, Unable to load your collection due to an error. Sriphojanart T, Khunkhet S, Suchonwanit P. A retrospective comparative study of the efficacy and safety of two regimens of diphenylcyclopropenone in the treatment of recalcitrant alopecia areata. Pityriasis rosea and pityriasis rosea-like eruption after anti-SARS-CoV-2 vaccination: a report of five cases and review of the literature. and transmitted securely. Accessibility doi: 10.1111/ijd.15700, 4. Common causes of drug-induced PR-like eruptions include angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, and gold. We originally reported patients with COVID-19 [2], Abstract Dear Editor, Pityriasis rosea (PR) is a common, self-limited erythematous papulosquamous dermatosis that mainly affects young adults. 2023 Apr;11(4):e804. SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. Accessibility The rash typically lasts 6-9 weeks, rarely extending longer than 12 weeks. All patients are currently in good general health. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. The https:// ensures that you are connecting to the 7 Articles, This article is part of the Research Topic, Creative Commons Attribution License (CC BY), Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. It is important for physicians to be aware of this self-limited reaction so they can reassure and appropriately counsel patients that it is safe to receive subsequent vaccine doses despite the cutaneous eruption. 2023 The Authors. The significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations. Bethesda, MD 20894, Web Policies Keywords: 2022 Feb 3;9 (2):003164. doi: 10.12890/2022_003164. Moreover, while dermoscopy may facilitate the diagnosis of PR, its utility for atypical PR or PR-like lesions is still limited. An official website of the United States government. CONCLUSION: The association between pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccines was established, but given the scarcity of studies, there is a need to conduct different clinical trials to confirm this association further and study the etiology and mechanism of the disease. However, in cases of atypical PR, it may present with erythema multiforme-like lesions and purpura (5). Please enable it to take advantage of the complete set of features! 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. doi: 10.1002/iid3.804. Pregnant women are in a high-risk group for serious complications from pityriasis rosea. Cutis. Although the most severe manifestations concern the lower respiratory tract, COVID-19 is a multiorgan disease that also affects the skin. Apply a moisturizer, calamine lotion or a nonprescription . Drago F, Ciccarese G, Rebora A, et al. . the reactivation of varicella zoster or herpes simplex infections, pityriasis rosea or rosea-like lesions, petechiae, pernicious purpura . Unauthorized use of these marks is strictly prohibited. and transmitted securely. Bookshelf Zhongguo Dang Dai Er Ke Za Zhi. and the adverse cutaneous effects of COVID-19 . Epub 2021 Jul 21. 1. doi: 10.1111/ijd.13061. Keywords: In a Spanish study,PR/PRLE was observed in 11 patients (6.7%) vaccinated with BNT162b2, in 5 patients (3.4%) vaccinated with mRNA- 1273 and in 4 patients (4.2%) vaccinated with AZD1222.2 Available data suggest that BNT162b2 vaccine is more related to PR/PRLE than other vaccines. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Environ Sci Pollut Res. 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. J Eur Acad Dermatol Venereol. HHS Vulnerability Disclosure, Help 8600 Rockville Pike (2006) 12:1. doi: 10.5070/D380D8301D, 11. doi: 10.1002/iid3.804. Due to the temporal relationship between vaccination and onset of rash, COVID-19 vaccination was the most likely etiology. Unable to load your collection due to an error, Unable to load your delegates due to an error. The https:// ensures that you are connecting to the 2021;35(8):e489e491. Mohta A, Nyati A, Mohta A, Ghiya BC, Mehta RD, Kumar V. Indian Dermatol Online J. COVID-19 vaccine hesitancy is a critical problem that hinders Please enable it to take advantage of the complete set of features! However, after 14 days, she developed multiple discrete blanching erythematous oval patches and plaques on the lower abdomen, back, and bilateral upper thighs (Figures 1A,B). Cureus. KL drafted the original manuscript. The length of the rash is shorter in comparison with PR.19. Since you said you felt ill at the time getting the vaccine you had covid at the time. doi: 10.1111/dth.15040, 3. Clipboard, Search History, and several other advanced features are temporarily unavailable. . The coronavirus disease 2019 (COVID-19) pandemic is filling the headlines these days. (2016) 30:5445. Suchonwanit P, Hector CE, Bin Saif GA, McMichael AJ. KL and KP collated resources. The most commonly inoculated vaccines include those against smallpox, followed by tuberculosis, poliomyelitis, influenza, and human papillomavirus virus (12, 13). Pityriasis is linked mainly with herpesviruses 6 and 7; only a small number of cases have been reported in association with vaccinations (e.g., yellow fever, influenza, hepatitis B, human. Dermatol Ther. Suchonwanit P, Leerunyakul K, Kositkuljorn C. Cutaneous manifestations in COVID-19: Lessons learned from current evidence. The rash can be itchy. In some cases, central hyperpigmentation was identified. Within two weeks of topical betamethasone dipropionate treatment, the lesions disappeared completely. doi: 10.1007/s10103-019-02783-8, 16. However, several adverse effects of COVID-19 vaccination have been identified. Moles, psoriasis, hives, eczema, and recently associated Covid-19 coronavirus rashes are just a few of the more than 3,000 skin disorders known to dermatology. This site needs JavaScript to work properly. FOIA 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. Dermatol Online J. 8600 Rockville Pike Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. Vaccine-Related Eruptions of Papules and Plaques Following COVID-19 Vaccination - A Case Series. Central dusky-red erythematous on some plaques (A); almost all lesions fading with associated post-inflammatory hyperpigmentation after treatment (B). Epub 2022 Jun 13. Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of COVID19. However, some hypotheses may be advanced: i) PR/PRLE following anti- Sars-CoV-2 vaccination may be just a coincidence, for instance in those patients in whom PR/PRLE appeared only one day after vaccination;4,12 ii) anti-Sars-CoV-2 vaccines cause a reactivation of HHV-6 and/or HHV-7, which is similar to the reported association with herpes zoster;1,9 iii) vaccines can induce a delayed hypersensitivity response clinically similar to druginduced PRLE.10. JAAD Case Rep. 2021;7:9394. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. . 2022 Nov-Dec;67(6):802-804. doi: 10.4103/ijd.ijd_562_22. JAAD Case Rep. (2018) 4:8001. Among patients who received COVID-19 vaccines, PR-like eruptions have been reported following the first (n = 1) or second dose (n = 2) of BNT162b2 mRNA-based vaccines (3, 4). Khan I, Elsanousi AA, Shareef AM, Tebha SS, Arif A, Gul S. Immun Inflamm Dis. Br J Dermatol. and transmitted securely. Epub 2022 Jul 19. Epub 2022 Jan 5. Peripheral eosinophilia is often present. Table 1. Numerous scattered erythematous plaques with fine scale oriented along skin cleavage, Herald patch of pityriasis rosea. There are four main types of vaccines and over 240 candidate vaccines in development. Numerous scattered erythematous, Pityriasis rosea. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. The third type of rash, known as Covid fingers and toes (sometimes described as chilblains), is where red and purple bumps appear on the fingers or toes.. doi: 10.1111/jdv.12942, 13. Accessibility Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine. An official website of the United States government. The pathogenesis of this relationship is unknown. Pityriasis rosea and pityriasis rosea-like eruptions: how to distinguish them? Federal government websites often end in .gov or .mil. 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. HHS Vulnerability Disclosure, Help Bethesda, MD 20894, Web Policies Clin Dermatol. J Eur Acad Dermatol Venereol. Before Postgrad Med J. Treatment with topical 0.1% triamcinolone acetonide twice per day showed partial response after seven days. official website and that any information you provide is encrypted Cebeci Kahraman F, Sava Erdoan S, Akta ND, Albayrak H, Trkmen D, Borlu M, Arca DA, Demirba A, Akbayrak A, Polat Ekinci A, Gkek GE, elik HA, Taolar MK, An , Temiz SA, Hazinedar E, Ayhan E, Hzl P, Solak E, Kl A, Ylmaz E. J Cosmet Dermatol. The duration of the infection ranges from two weeks to three months. Figure 3. The .gov means its official. Bethesda, MD 20894, Web Policies (2020) 33:e13650. HHS Vulnerability Disclosure, Help doi: 10.1111/jdv.17342. A Yale-led study published in the journal Immunity in May offers a few theories on why some children develop MIS-C and others don't. HHS Vulnerability Disclosure, Help Akdas E, Ilter N, Ogut B, Erdem O. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. Table 1 summarizes all reported cases of PR-like eruption following COVID-19 vaccination. doi: 10.1016/j.jaad.20.2103.092. Sprinkle bath water with an oatmeal-based bath product (Aveeno). government site. The. The site is secure. Dear Editor, Pityriasis rosea (PR) is a common, self-limited erythematous papulosquamous dermatosis that mainly affects young adults. doi: 10.1111/jdv.17316, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. The site is secure. No use, distribution or reproduction is permitted which does not comply with these terms. -, Carballido Vzquez AM, Morgado B. Pityriasis rosea-like eruption after PfizerBioNTech COVID-19 vaccination. It manifests as oval-shaped, pink or red . Epub 2022 Feb 9. sharing sensitive information, make sure youre on a federal The authors declare no conflict of interest. Federal government websites often end in .gov or .mil. *Correspondence: Poonkiat Suchonwanit, poonkiat@hotmail.com, ORCID: Kanchana Leerunyakul orcid.org/0000-0002-0669-5611Kallapan Pakornphadungsit orcid.org/0000-0003-4783-0282Poonkiat Suchonwanit orcid.org/0000-0001-9723-0563, COVID-19 Associated Cutaneous Manifestations and COVID-19 Vaccine Related Skin Reactions, View all

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