Thanks! MENTS my 3rd FET was a success end MENTS. END MENTS. Its so heartbreaking but Im trying to find some hope so I can move forward. However, that information will still be included in details such as numbers of replies. This can be done! So in your case it might be different since yours are chemical pregnancies but still worth asking I think :) Also someone above mentioned the endometrial biopsy which would also probably be a good idea. Does PGT-A reduce the chances of miscarriage? thank you so much! My FET is at the beginning of June so hoping that with this adjustment, a better outcome will occurs. Did our first FET in October with a supposedly PGT normal embryo. Reply Share React operationpepper Dec 22, 2015 3:42 PM By screening out abnormal embryos with PGS, physicians can transfer just one chromosomally normal embryo, increasing the chances for having a successful singleton pregnancy and healthy child. However, theirsample sizewas small. For more background info, check out my post onPGS Testing. Should I just ask for this to be done regardless? I hope the ERA works too. Chances for getting a euploid embryo A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Donor eggs: 63.1% euploid <35 years: 59.5% euploid 35-37 years: 50.3% euploid 38-40 years: 38.3% euploid 41-42 years: 26.8% euploid 43-44 years: 24% euploid Im so sorry to hear about your losses but so happy with your current miracle. The chart below, based on information published in Reproductive Biomedicine Online, in 2016, shows:. For your second question, Ill be doing an Embryo News this week that explains a study that compares non-PGS vs PGS tested embryos. Aww happy your second round worked! Even though I ended up with no good embryos I recommend it because I think it's good to know now and not later with a miscarriage. Your clinic may have a better idea! Please whitelist our site to get all the best deals and offers from our partners. I know this is an incredibly hard time and it's a tough decision- best of luck to you- don't give up hope. No PGS testing Please don't give up! Thought this was tested out, but apparently that can't be detected by the PGT test. Question about blastocysts and PGS testing - we got 12 eggs / 7 mature / 7 fertilized with ICSI and 2 grew to 6 days. I've read that in a non-IVF pregnancy, the rate of miscarriage is about 21.3% between weeks 5 and 6. I completely understand struggling about whether to do the 3rd retrieval, it is a lot to go through all over again. (2018)found a slight reduction inlive birth ratecompared to single biopsied embryos (50% vs 58%), but this was notstatistically significant. I had also changed from an estradiol tablet to estradiol patches in my first FET. PGS/PGT-A success rates can vary. no, I just took those 3. Best of luck to you with your upcoming FET, my thoughts and prayers are with you! I know Im my heart I want to try again, but my brain is working overtime too - odds, finances, and the risk of suffering all over again, Im so sorry to hear all this! Last year I got pregnant from an IUI and miscarried at 8 weeks. For that reason my RE said she would start testing such as ERA after a second failed transfer but didnt think it was necessary after the first failed transfer. So weve been ttc for almost 2 years. Trying to be strong and not make the holidays about my loss for the sake of my family, not sharing the news either until after. (2018)looked at about 650 transfers ofPGS tested euploidembryos (based onSNPtechnology) across various ages: So it looks like the success rates hover around 60-70% in most cases, with women >42 having about a 50% live birth rate per transfer. According to the authors, the >35 group analysis should be interpreted with caution as the sample size was small. Definitely heartbroken but trying to look forward. I cried the whole way home. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. And since then Ive had medical issues that havent allowed me to try again until last month. . Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. I had a PGT normal day 7 embryo that unfortunately resulted in a chemical. My husband and I started trying to get pregnant about a year ago (we're both 35). The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Find advice, support and good company (and some stuff just for fun). Be sure to read the next two sections to get an idea of how grades and growth rates (Day 5, 6, 7) affect IVF with PGS success rates, as well as this section further down. Thank you Its so hard when youre paying yet your doctor doesnt think its needed. During my first IVF cycle, when we only created 2 normal embryos out of 18 eggs (my husband's sperm is great), it seemed like embryo quality would have explained the first two chemical pregnancies. Did your RE have you take anything other than progesterone and estrogen and aspirin? Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). 2 - IVF BFN I went into my second egg retrieval and got less eggs than the first time around. I know Im shocked this was never brought up by my doctor, after everything. Im glad you took time for your mental health. We are so happy about that, we just want this one to be the one. Sometimes something as small as a polyp that can be removed, can cause implantation to fail. I did acupuncture that cycle. There is much better chance of IVF success with PGS testing in women who were over the age of 35. So mosaics can have a varying rates of miscarriage depending on the type of abnormality present. If your protocol did not have one or the other perhaps you can ask your RE about it. And demand that my lining be over 8 before I allow another transfer to occur? She is pregnant right now from that cycle. Note that once you confirm, this action cannot be undone. For women who have it, REs may suggest prednisone and lovenox after transfer. Sounds like a beautiful a rainbow miracle! Pre-implantation Genetic Testing for Aneuploidies (also known as PGT-A, or historically known as PGS or CCS) is a diagnostic tool to tell your fertility doctor which embryos are likely to be chromosomally-normal and thus which to transfer. Hi everyone. Hi, i didnt have chemicals, I had bfn for my first two transfers. You said that The per retrieval statistic helps to see the chances before PGS testing. But it almost seems like there should be another set of statistics for better putting success rates into perspective. These are said to help in cases with failed transfers or previous miscarriages because it calms down your system to accept the embryo, where without sometimes your immune response would attack it as something foreign. I feel so lucky that I found this community. Design: Case-control study. To count these women in, we can look at the per retrievaldata: Now when we look at everyone the stats look much different! MENTS I am also going through a chemical pregnancy this week, but with an untested embryo (so, that's very likely the reason for my loss). (2016)found nostatistically significantdifference inongoing pregnanciesbetween Day 5 and 6 euploids (78.6% vs 67.4%), but this was reduced by Day 7 (43.8%). This was my only PGS normal embryo so I have to re-do that as well.. Dear RLM11, so sorry for your losses, I know how devastating it is! Im assuming as the levels drop theyll wean me off. Has anyone had a similar experience but had a viable pregnancy. I had a chemical last November with a PGS normal embryo and was successful with the second FET in July. To perform the biopsy, an embryologist removes 2-10 cells from the precursor placenta cells of the blastocyst embryo, called the trophectoderm. Hello, I had been on birth control since I was 18 and had no idea what to expect when I came off it. We got to see and hear the heartbeat yesterday. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. I was put on the Schoyer protocol for stimulation. (The embryo split!) MENT I got a natural BFP at 34yo with an FSH of 38 and had no issues with my pregnancy. what were the extra things you did besides Lovenox/prednisone, biopsy and ERA? Next lets look at how mosaics perform in terms of miscarriage (often using euploids as a control so for you euploid people out there, you might want to check the next section also!). However, another doctor (2nd opinion) claimed that Receptiva would only be conducted for implantation failure and for those who had never seen positive pregnancy tests. Does it still matter? Theper retrievalstatistic helps to see the chancesbefore PGStesting. If you did PGS after multiple miscarriages and failed attempts how many did you transfer? Then for my second FET we did an unmedicated FET and it worked. After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. I hope this gives you some hope. Inconclusive or No Result biopsies may require a second round of biopsy aka a rebiopsy. They found a reduction in live birth rates (50% to 39%), although this was notstatistically significant(it was from a small study). We put both in and im currently 8weeks pregnant. Obviously this is not an ideal situation but sometimes this happens. I was wondering what protocol were you on for your second transfer? Its good you will request the endomitritis biopsy. Setting: University-based fertility center. With the retrieval statistics, we can include all cycles (like the ones that ended with no blasts to transfer or only abnormal embryos that werent transferred) and that lowers the success rates quite a bit. All that to say, it's likely that there actually was something wrong with that embryo - but it's worthwhile to leave no stone unturned before trying again. The majority of these studies used double embryo transfers, either when transferring euploid embryos, in the control untested groups, or both. I expect a call from my RE tomorrow, will ask about both of your suggestions, the immune protocol and antihistamine and see what she thinks . Apparently some women have different windows of, Implantation and I found out this week that I need 24 hours additional progesterone which could be the reason for the other chemicals. Mosaics are embryos that have a mix of euploid and aneuploid cells. also did you have to do another stim cycle? Consult with your doctor before making any treatment changes. Ill also update this blog to include that info. This study is considered the best quality evidence currently available for PGT-A (which showed no benefit over traditional grading for women <35 that you read about that here). This isnt very surprising considering these embryos have no cells that are euploid in order to self-correct (read more about that here). Wishing you lots of luck. The embryo biopsy can be utilized to perform preimplantation genetic screening or PGS. If you have not I would suggest an embryo scratch/biopsy before your next FET. Good luck and wishing baby dust your way soon! I have a similar story. Unfortunately this isnt very clear at this point. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. More studies need to be done. The results come back as euploid (meaning theres 46 chromosomes), aneuploid (meaning theres a number of chromosomes besides 46) or mosaic (meaning theres a mix of euploid and aneuploid cells). Trade-offs of PGT-A (or PGS) I also went for a lot of second opinionsall of the drs said there were many reasons and theories for why pgs embryos fail but its not uncommon. Im sure that data exists especially since thats how things used to be done back in the day. Thanks so much for sharing! Im so sorry for your losses. I actually didnt have embryos to bring with me when we switched. Both Chemical pregnancies my lining was under 7. So most <35 women are between 30-90% chance ofeuploid(61% is the average). If you have any questions about my protocol happy to answer. We timed everything to my cycle. I am 39 turning 40 this year. Multiple losses due to chromosomal abnormality, did you do ivf? Hi.all0130could you tell me what kind of endometrial scratch biospy you did?hi.T3bk.you did endometrial scratch biospy too?which one you did?era.yale eft.or something else? Then a frozen cycle BFN. thats a great suggestion! Segmental aneuploids: the main source for PGT-A false positives? Disclaimer: Any studies presented here may be contradicted by other studies. There was a greater reduction in the >35 group (10.4% for PGT-A vs 27.9% for untested) compared to the <35 group (13.3% for PGT-A vs 16.1% for untested), however neither of these analyses were statistically significant. As for boosting chances with two put back it should not be the trick. wow, Im so glad you were able to get a second opinion. I also tested positive for anti-thyroid antibodies. If you want to read more about about success rates for untested embryos, go to my embryo grading and success rates post. Patients often hear "PGS-normal embryos have a 60 - 70% success rate." But that is on a per-transfer basis. Kelly. Neal et al. I was told by my doctor that when it is a PGS embryo that is miscarried, it is a 50% chance it was something else with the embryo (structural issues with the organs or placenta) and a 50% chance it was something about the moms body. My current doctor reviewed my history and suggested an endometrial biopsy for endometritis (different from endometriosis). I needed additional days of progesterone and that was corrected for my 2nd FET. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Thanks again! Well start with euploids, then mosaics, and end with fully aneuploid embryos. I will talk to my dr about all of the above and hopefully i can finally get some answers :) My dr keeps pinning it on my lining but it doesnt make sense to me since Ive been over 8mm with a triple line pattern each chemical. After a chemical with 2 PGS normals and two miscarriages around 8 weeks (spontaneous pregnancies) and another failed transfer, I found out I had an infection in my lining that can only be detected by a biopsy. 12 43 comments Best Add a Comment gundacurry 2 yr. ago https://www.fertstert.org/article/S0015-0282 (17)31371-7/fulltext lennylincs 2 yr. ago Started with 14 eggs, 7 fertilized and only 1 made it to blast and ended up being abnormal. We had 4 blasts tested in our first IVF cycle and 2 were abnormal / 1 mosaic / and then 1 "normal". When we started I was told by an RE I had a 2% chance of having a baby with my own eggs. I am not naive I know bad things can happen. I only have embryo left ugh . My second was ectopic, my third was a failure and Im about 7.5 weeks pregnant from my 4th (). My current success was a FET with NO meds except vaginal progesterone. - 2 Day 5's transferred ended in a chemical pregnancy; 1 perfect Day 6 blast ended up making me a mom. I am so frustrated, disappointed, hurt, sad and angry right now. It's my second transfer. 4 PGT-M and PGT-A vs. Prenatal Testing Sending you lots of love, hope and positivity! For now its probably best to avoid having to thaw and biopsy if possible. But Im wondering how those numbers have changed with other advancements in infertility medicine. I am just torn. As someone else mentioned adding prednisone, I also had a steroid but mine was the Medrol Dose pack which is basically the same idea. Odds of success are roughly 70 percent. So they were both frozen on Day 6? Best of luck! (2019) STAR trial represents the best data that we have currently, and it shows no benefit with PGT-A reducing miscarriage in the general population. Looking for anyone who has had recurrent chemical pregnancies and then found success. Its very disheartening though. My RE also encouraged us to just try another transfer rather than an ERA after our first chemical but then was on board after the second chemical happened. At this point I am waiting to start my 5th miscarriage. I guess this probably qualifies me as a poor responder which obviously doesn't feel good after all the other issues we've had. Segmental mosaics or single chromosome mosaics tend to perform better than multiple chromosome abnormalities which can approach 50% miscarriage rates. Have you been tested for APS (antiphosolipid syndrome)? Zhao et al. I am so frustrated and emotional, I am not having any pregnancy symptoms, beside some minor vaginal cramping and sore breast. Or is it worth having the actual tests done? Sending you positive thoughts . So maybe youve had a cycle and your embryos are frozen, and now you want them biopsied. Took THREE rounds of antibiotics for mine to clear. I have expressed my concern but my RE believes it is more about the pattern. He suggested an endometrial biopsy instead. Please specify a reason for deleting this reply from the community. The psychologist who ran the group, who also happened to be an RE at my fertility clinic, explained that sometimes you have a seemingly perfect embryo, perfect uterine lining, and the FET just fails. Some of the reasons quoted werent even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, theres a margin of error with the testing itself, pgs doesnt tell us everything about an embryo, etc. Did testing and just found out it was a triploid embryo so it had 69 chromosomes. But it seems like the majority of twin pregnancies result in healthy babies. Might be worth asking about. Im currently 17 weeks from another FET. Just thought Id throw this test out there though! my first 2 cycles were artificial but my last 2 were natural and unfortunately no luck :( Hopefully we can get somewhere with the ERA. He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. Terms are highlighted every 3rd time to avoid repetition. I guess I'm facing wasting the investments of stimulation vs potentially wasting the investments in proceeding but also getting more information that might help with future cycles. So the advantage with PGT-A may be in determining which embryos are completely unfit for transfer, at least based on this study. It definitely won't hurt to ask your doctors about an antihistamine protocol, I don't remember the exact dosages I took or how long. But wait! Which was Claritin, pepcid, and baby aspirin. It was an incredibly long and intense process but looking back I did not have time on my side for my eggs so it was the right decision for us. It worked and now I'm 24 weeks pregnant with twins! Though it's one of the most successful forms of assisted reproductive technology, the live birth rate from one IVF cycle is about 55.6% for people under 35, and 40.8% for folks between the ages of. Congratulations on your pregnancy xxx Single embryo transfer both times. Again, Im sorry if thats not helpful especially since your RE didnt think it was necessary for you but that was just my experience. So what if the embryos are euploid? Then another IVF/ICSI but nothing to transfer-- my doctor switched up my meds which was a bad idea obviously. We are currently looking to use a gestational surrogate in Texas. PGT-A is able to evaluate the % of cells that are abnormal in a biopsy sample and if theres a mix of euploid and aneuploid cells then the embryo is a mosaic. Did you get your BFP on IVF post the antibiotics or naturally? Ive had two chemicals and my RE suggested doing an endometrial receptivity assay (ERA). So I tried to find information through the site because I know topics like this have been posted before, BUT when I pull the results somehow PGS results in a whole lot of pregnancy posts as pg is used as a shortcut, and I am so all set with that. Hi Mogwai_2 Theses are rates for PGS normal embryos. My husbands sperm analysis was only very slightly abnormal. Overall, I really wish clinics and REs were more straightforward about odds of success esp with pgs since I think they can be a little misleading. We are at a loss as both embryos transferred (one late last year and one last month) were PGS normal. Very frustrating to have an inconclusive. Lack of common pregnancy symptoms like morning sickness or breast soreness after a positive pregnancy test. At the time, I was at rock bottom and going to an online support group. We started some workup with my OB (TSH, karyotyping and carrier testing). After my negative, we did ERA and had a hysteroscopy to correct a small septum. According to the geneticist, there is as much chance it could be completely normal as the chance that it is abnormal. Or a fully aneuploid embryo? What would they tell me and how would they impact protocol differently?

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